Histone H2B: A Potential Drug Target with Broad Implications (P40582)

Target Name: Histone H2B

NCBI ID: P40582

Histone H2B

Other Name(s): Histone H2B | H2B

Histone H2B: A Potential Drug Target with Broad Implications

Histone H2B, also known as nonspecified subtype, is a type of histone that is found in various cell types of the human body. It plays a crucial role in the regulation of gene expression, DNA replication, and chromatin structure. Histone H2B is composed of two histone proteins, H2A and H2B, which are held together by a disulfide bond.

Histone H2B is a key player in the histone complex, which is a protein-protein interaction network that makes up the nucleosome, the basic unit of chromatin. The histone complex plays a vital role in regulating the expression of genes, as well as the replication and repair of DNA.

One of the unique features of histone H2B is its ability to interact with a variety of different proteins, including histones H1, H2A, and H3. This interactivity makes histone H2B a potentially interesting drug target, as it may have a wide range of effects on cellular processes.

Histone H2B has also been shown to play a role in the regulation of cell signaling pathways. For example, it has been shown to interact with the protein kinase A-TAT, which is involved in the regulation of cell growth and differentiation. This interaction may have implications for the development of cancer, as increased levels of A-TAT have been linked to the development of cancer.

Another potential drug target for histone H2B is its role in the regulation of cell apoptosis, or programmed cell death. Histone H2B has been shown to play a role in the regulation of apoptosis in various cell types, including cancer cells. This may have implications for the development of new treatments for cancer.

Histone H2B has also been shown to play a role in the regulation of cell migration and the formation of tissues. For example, it has been shown to interact with the protein vimentin, which is involved in the regulation of cell migration. This interaction may have implications for the development of new treatments for diseases such as cancer.

In conclusion, histone H2B is a protein that plays a crucial role in the regulation of various cellular processes. Its ability to interact with a variety of different proteins makes it a potentially interesting drug target. Additionally, its role in the regulation of cell signaling pathways, apoptosis, and cell migration may have implications for the development of new treatments for a variety of diseases. Further research is needed to fully understand the unique mechanisms of histone H2B and its potential as a drug target.

Protein Name: Histone H2B (nonspecified Subtype)

The "Histone H2B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about Histone H2B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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